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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL4
All Species:
22.12
Human Site:
S288
Identified Species:
37.44
UniProt:
Q5MAI5
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5MAI5
NP_001009565.1
315
36223
S288
L
E
S
S
Y
F
D
S
F
Q
E
A
Q
I
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001103311
378
43278
S288
L
E
S
S
Y
F
D
S
F
H
E
D
Q
I
K
Dog
Lupus familis
XP_851459
362
41706
S308
L
E
S
P
Y
F
D
S
F
H
E
D
H
I
K
Cat
Felis silvestris
Mouse
Mus musculus
Q3TZA2
342
39427
S288
L
D
S
A
Y
F
E
S
F
Q
E
D
Q
M
K
Rat
Rattus norvegicus
Q66HE7
352
40881
S289
L
Q
H
P
Y
F
D
S
I
R
D
V
G
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514378
352
40807
S289
L
Q
L
P
Y
F
N
S
L
R
D
T
E
D
L
Chicken
Gallus gallus
P13863
303
34670
D289
L
N
H
P
Y
F
D
D
L
D
K
S
T
L
P
Frog
Xenopus laevis
P23437
297
33852
T282
I
S
A
K
V
A
L
T
H
P
F
F
R
D
V
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
S289
L
E
Q
P
Y
F
D
S
L
R
E
E
S
E
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608950
501
57855
D400
T
K
H
S
Y
F
D
D
Y
I
A
K
Q
R
E
Honey Bee
Apis mellifera
XP_394980
385
44993
N314
L
Q
H
L
Y
F
E
N
F
H
F
K
M
P
E
Nematode Worm
Caenorhab. elegans
NP_505823
353
40647
N288
M
L
H
G
I
F
S
N
W
I
L
R
I
R
Q
Sea Urchin
Strong. purpuratus
XP_787618
363
41882
R291
M
E
M
P
F
F
D
R
H
K
G
L
D
D
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
T277
Y
E
P
S
K
R
I
T
A
R
Q
A
L
E
H
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
79.8
80.3
N.A.
83.3
62.7
N.A.
62.5
38.4
38
64
N.A.
38.7
51.4
53.8
56.4
Protein Similarity:
100
N.A.
81.2
83.1
N.A.
90
76.6
N.A.
75.8
57.4
60
77.7
N.A.
51.5
67
70.5
71
P-Site Identity:
100
N.A.
86.6
73.3
N.A.
66.6
33.3
N.A.
26.6
26.6
0
46.6
N.A.
33.3
26.6
6.6
20
P-Site Similarity:
100
N.A.
86.6
73.3
N.A.
93.3
53.3
N.A.
60
46.6
26.6
53.3
N.A.
53.3
53.3
33.3
46.6
Percent
Protein Identity:
N.A.
35.8
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
56.8
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
20
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
40
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
8
0
0
8
0
8
15
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
0
58
15
0
8
15
22
8
22
0
% D
% Glu:
0
43
0
0
0
0
15
0
0
0
36
8
8
22
15
% E
% Phe:
0
0
0
0
8
86
0
0
36
0
15
8
0
0
0
% F
% Gly:
0
0
0
8
0
0
0
0
0
0
8
0
8
0
0
% G
% His:
0
0
36
0
0
0
0
0
15
22
0
0
8
0
8
% H
% Ile:
8
0
0
0
8
0
8
0
8
15
0
0
8
22
0
% I
% Lys:
0
8
0
8
8
0
0
0
0
8
8
15
0
0
29
% K
% Leu:
65
8
8
8
0
0
8
0
22
0
8
8
8
8
15
% L
% Met:
15
0
8
0
0
0
0
0
0
0
0
0
8
8
0
% M
% Asn:
0
8
0
0
0
0
8
15
0
0
0
0
0
0
0
% N
% Pro:
0
0
8
43
0
0
0
0
0
8
0
0
0
8
8
% P
% Gln:
0
22
8
0
0
0
0
0
0
15
8
0
29
0
8
% Q
% Arg:
0
0
0
0
0
8
0
8
0
29
0
8
8
15
8
% R
% Ser:
0
8
29
29
0
0
8
50
0
0
0
8
8
0
8
% S
% Thr:
8
0
0
0
0
0
0
15
0
0
0
8
8
0
0
% T
% Val:
0
0
0
0
8
0
0
0
0
0
0
8
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
72
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _